Desethyl piperacillin, a new active metabolite of piperacillin in human.

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Desethyl piperacillin, a new active metabolite of piperacillin in human.

metabolites in human. In the course of clinical study for the coadministration ofPIPC with a /Mactamase inhibitor, tazobactam3), an active metabolite ofPIPC (1) which is distinct from T-1220A was found in human plasma and urine. The metabolite 1 was also found in the same manneron the administration of PIPCalone, suggesting that the metabolism of PIPC was not affected by the co-administration o...

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Piperacillin: in vitro evaluation.

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Piperacillin-tazobactam penetration into human pancreatic juice.

Piperacillin-tazobactam was administered as a single dose (4.5 g intravenous) to five patients with stabilized external pancreatic fistula. The penetration into pancreatic juice was prompt, and inhibitory concentrations were achieved and maintained for different periods (0.5 to 6 h) according to bacterial susceptibility and patients' characteristics. Piperacillin and tazobactam showed superimpo...

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UNLABELLED Neutropenia, secondary to immune destruction or maturation arrest, is the most commonly described adverse haematological effect of beta-lactam antibiotics. We describe a case of reversible pancytopenia, with evidence of hypocellular marrow, after a prolonged course of piperacillin/tazobactam for 26 days. KEYWORDS Piperacillin; Tazobactam; Myelosuppression; Neutropenia.

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This is the first reported detection of serum IgE antibody to piperacillin-human serum albumin (HSA) conjugate in a patient presenting with anaphylaxis that developed after occupational exposure. A 24-yr-old nurse, who had worked at a University Hospital for 2 yr, experienced chest tightness, dizziness, generalized urticaria, abdominal pain, and diarrhea 10 min after administering a piperacilli...

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ژورنال

عنوان ژورنال: The Journal of Antibiotics

سال: 1991

ISSN: 0021-8820,1881-1469

DOI: 10.7164/antibiotics.44.256